Metformin is one of the crucial prescription drugs used to treat insulin resistance by enhancing the body’s response to insulin. It is mostly used for alleviating the symptoms of type 2 diabetes. This drug could be one of the ultimate solutions for relieving symptoms of patients with the chronic syndrome. At present, metformin is approved only for the treatment of insulin-related diseases and polycystic ovary syndrome. However, there are high chances that it may be used for treating the chronic disease off-licence since there is no solid proof directly linking insulin resistance and chronic pain disorder. Currently, a patient’s prescription depends on the decision of his or her physician. Mostly, the drug is prescribed alongside other medication, including antibiotics.