What You Need To Know About Amitriptyline For Fibromyalgia

amitriptyline for fibromyalgia

Different types of pharmaceutical drugs are being prescribed to fibromyalgia patients. They include non-steroidal anti-inflammatory medications, muscle relaxants, sedatives, as well as antidepressants. Amitriptyline, belonging to the oldest type of antidepressants, is a common drug administered by fibromyalgia patients.

What Is Amitriptyline?

Amitriptyline is a type of tricyclic antidepressant (TCA ), mainly used in treating clinical depression. This class of antidepressants has some of the oldest antidepressants still in use. Amitriptyline, sold under the brand Elavil, is believed to be one of the most efficient antidepressants. However, in spite of its effectiveness, newer antidepressants are favored over Amitriptyline due to its side effects and toxicity when over-consumed.

Although approved by the FDA for treating major depressive disorders, Amitriptyline has not been approved by FDA as a fibromyalgia medication. However, it can also help in anxiety disorders and nerve-related pain conditions such as fibromyalgia.


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  • I tried amitriptyline for my fibromyalgia and depression. I found it eased my tension not so much my pain and eased depression but unfortunately I did gain weight which didn’t help with physical ability which is vital for fibromyalgia and my eyes got very sore and blurred vision. I’m still at a loss with a tablet that can help without side affects. I am very tired all the time and there is not a tablet that helps with fibromyalgia without it making you sleepy.

    • About 12 years ago, I was having awful head pain, not a headache, but pain radiating on the left side of my head from the temple and around my ear. My PCP prescribed Tegretol, but my white blood cell count became dangerously low so she switched me to Lyrica. I had horrible side effects from the Lyrica, especially mental confusion and loss of balance. So she prescribed Gabapentin. She thought I had Trigeminal Neuralgia. She also sent me to a neurologist, who did nerve conduction tests and other tests. He downgraded the neuralgia to Occipital Neuralgia. He prescribed Amitriptylene for the widespread pain. After a couple of years of putting up with pain, another neurologist in the same practice said I fit everything on a checklist for Fibromyalgia. He sent me to a rheumatologist. She prescribed Duloxetine and confirmed I had Fibromyalgia. I now take 75 mg of amitriptyline at bedtime, 60 mg of Duloxetine at night, and 600 mg of Gabapentin two to three times each day. My pain is controlled fairly well now. When the weather takes a turn for the worse or it gets damp and humid, I get achy. My main problem is that I have chronic fatigue. I try to exercise and work through it. I have taken 3 hour naps some days. There are times when I cannot sleep well at night, even when I do not take a nap.

    • i take Amitriptyline 100mg at night , couldnt do without it , i sleep better but morning stiffness stil there , hubby has to pull me upright to get me out of bed

    • I was on 10mg. Amytriptyline at bedtime for 12 years and it did help with sleep and pain and allowed me to work full-time.
      When I retired I took 6 months to wean off it as I read in many medical journals that it increased risks of dementia. I did notice the difference and my pain increased. I am now on CBD oil and magnesium. I prefer not to take meds if possible.

  • I am no longer allowed amitryptiline as I take citalipram and apparently the two together can cause heart problems. I am desperate to find a replacement for amitriptyline as it was the only drug that effectively eased nerve pain that radiates through my neck, arms, shoulders and chest periodically. This pain becomes excruciating, even inducing vomiting, and amitriptyline took the edge off and helped me relax. I will aske my GP about Duloxetine

    • I have had fibromyalgia and psyratic arthritis for six years. I’m finally on a combo of three pills. Cymbolta and gabapatin and hydroxyqiine. It help my pain a lot. But still get sore shoulders and back. AND I AM TIRED. All the time and have gained wieght because of it. No energy to go for long walks like I use to. Makes me sad. I use to be skinny. I use to work to jobs. I use to walk and bike every where every day. Pisses me off. We need a pill that doesn’t make us tired. So I tried dope in butter. Helped my pain. Thanks.

  • I am currently taking amitriptyline. I am using it more for sleep, than to help with my pain. I take Savella for my pain, which has helped me tremendously. But, I do understand that not everyone can take Savella. But, the amitriptyline has helped me get more sleep because I had been having a lot of difficulty with my sciatica. And I am also in the middle of my physical therapy.

  • I’ve been on this medicine for over 15 years. It helps with my pain some what but has helped my depression totally. Before nothing seemed to help especially muscle relaxer and other depression medicines. I’m thankful for my results because without this med I don’t think I would have such a great recovery!

  • I take amitriptyline for cvs. I have rheumatoid arthritis. I started taking it 2 years ago. I take 20mg. I think in a higher dose it would help. I have fiends with cvs who take 100my and they find they are in much less pain.

  • If i remember correctly, from over 30 yrs ago when I was finally dx with FM, i started with amitriptline, I was so exhausted waking up in the morning with 3 young kids under 10 yrs, a husband working shift work, I just couldn’t function and had to find something else. I dont remember what it was, but i do remember it taking a lots of trials to find a decent cocktail of meds to help my chronic depression and hypothyroidism that was dx too. Then the B12 defeciency and IBS which are common with FM.

  • Diagnosed 16 years ago, it was the only thing I was offered. I took half s tablet a day for a month, hardly slept in that time, when I did it gave me nightmares. I had flashbacks throughout the days and felt sluggish and drugged all the time. I refused more and didn’t want to try any others so was told I was on my own.

  • I’ve been on amitriptyline since 2009. It was prescribed by my PCP for headaches because I was waking up with daily borderline migraines. I have also have prescribed by my psychiatrist for depression and moods (fluoxitine, welbuteran in past) currently on Cymbalta/ duloxitine since 2012. Tried lyrica but every bad side effect happened so stopped it and am better off without it. My rheumatologist switched me from ibuprofen (was taking max dose Every dose and it ONLY dulled the pain) to indomethasin (much LESS of a dosage and pain relife). My pharmacist and insurance are questioning whether I STILL need the amitriptyline since I am on Cymbalta BUT bloodwork seems to be ok. I am also on Methatrexate arthritis and psoriasis and humerah So complicated healthwise especially since June 2016. Any suggestions on this mix?

    • Been on 50mg amitriptyline at night for 4yrs. It used to help with the pain and sleeplessness, but doesn’t seem to do a lot anymore. Have been advised to stay on it, as Dr says my moods, anxiety/depression will be unbearable. So, also have 30mg codeine phosphate at night, and for using in the day when pain levels are too much to handle.

  • I take 30mg amitriptyline 4 hours before bed for fibromyalgia. I used to take it just before bed but found my head was very foggy the next day and it took ages to “come to”. Taking the medication long before bedtime has proved very effective. I wake feeling much brighter and my pain is controlled. The advice on when to take my medication came from my chiropractor, not my GP and is the best I’ve received in treating my fibromyalgia.

  • I trotted amitriptyline but got no benefit or relief for pain, depression or insomnia. But what I did get were lots of side effects, groggy, foggy, and what else I don’t recall because out was 1998. My fiance uses it as he has fibromyalgia and myofasial pain syndrome. It helps him fall asleep. Nothing works for the severity of his pain but he hasn’t tried any other antidepressant. He’s been on gabapentin.

    • Gabapentin is awful for you and almost impossible to wean off. Try anything else. Cymbalta also a bad one. Check the Fibro website for articles and you’ll see they’re both awful on your system, especially with fibro.

  • It seems like every medication I have tried for fibromyalgia causes weight gain and many other side effects. The best treatment plan for me was gentle regular exercise and doing relaxation exercises like biofeedback an hour before bedtime works the best. Harder than popping a pill, but better for you all around.

  • I also have used amitriptylene but keep falling asleep while walking or standing still. This disease is beyond comprehension for most people but i can’t stand it. #iwantmylifeback!!

  • Yes at first it worked for sleep then after a year it didn’t. I was on 25 mg at night. I didn’t want to increase the dose.

  • I was on 40mg AMITITRIPTYLINE for 2 years. It helped with sleep, then stopped hello g me sleep. It helped with nerve pain a lot, but I gained 20 kilos and suffered severe constipation and other bowel problems. I have come off it and pain is back. I’m trying cbd oil now, which helps with sleep but not pain management. I have lost weight 10 kilos in two months since stopping Amitytriptyline and this has improved my overall wellbeing massively. I have to swim, yoga and walk regularly otherwise I completely seize up. I have also tried a self hypnosis audio book for pain management. I want my life back and generally feel better off meds than on. Despite the pain. Hopefully one day, they’ll find something without the horrendous side affects.

  • I was on amitriptyline 20 years ago BUT had irregular heart rhytm that was quite serious and cardiologist said NEVER take again. Have used gabapentin & Lyrica
    Since then. Am trying to switch to Cymbalta now because Lyrica is so exensi e.

  • Look at making golden paste, a turmeric based anti inflammatory which you make yourself. Thats all i take for fibromyalgia and arthritis in my spine. I managed to get off amitriptyline this year after being on it for 8 years.

  • I’m not 50 mg amitriptyline , helped with better sleep, but doesn’t help with joint pain. I’ve had bad sweating shoulders and head, a side effect , not regulating temp properly. I have put on weight. I’m stopping it as sweating is ridiculous.

  • I have been taking Amitriptyline 150 mg before bed since i was diagnosed back in 2004. I also suffer neuropathy, depression and anxiety but could not imagine going off it, its the only way I’m almost guaranteed 4 hours if sleep. I also suffer serotonin syndrome from taking so many sleeping pills.

  • I tried it for ages higher my dose as time went on then ended lowering it to come off due to not working anymore, was on a lot of codeine as well and went on to take cbd oil, diazapam and pragablin haven’t looked back. no opiates for me now cause then when I do need them later on in life I know they’ll work xx

  • DEB I have been on Amitriptyline since the 80;s after trying many drugs, air take10 mg at 9 pm and most nights sleep n8-9 hours. Not drowsy in am but still still and pain off and on.

  • I take Amitriptyline at night to help with the pain so that I can get some sleep. The fibromyalgia kept me in a fitful sleep before I was prescribed it and I would hate to have to give it up unless there was something that could do a better job without making me so tired in the mornings. To me, that is the only drawback from the medicine, just the time it takes to shake the grogginess but I will take that compared to not being able to rest at night. I have been on other medicines that cause me to pass out so this one is staying as long as my doctor allows me to take it.

  • I’ve used 10mg for fibromyalgia for 18 years. Slight dry mouth, only side effect. It does help with pain stiffness and sleep.

  • I was prescribed 10mg of elevil as a starting point for sleep, frequent urination during the night, and also for pain. I was also prescibed a NSAID for pain and it also helps with sleep…..as needed to a maximum of one in the am and one in the pm. I should say my do tor was a rheumatologist. Later I was prescibed Cymbalta starting at 30mg. For 2 weeks and increase to 60 mg. there after. Elavil, and Naproxen dosages remai ed the sameu til we had to tweak a bit higher with the the Elavil dose to 25mg for urine inconteñcy. That was the magical combination of medication that has controlled my fibro for 5 years now. I began a medication program for fibro when I was in my late 40’s. I gained some weight but am slowly managing to take it off. I have to say that the pain that I experience is well controlled and although I don’t like being dependànt on meds for my condition it is much better to take them and have a good quality of life with fibro than not. I am about to turn 61 in August and am pretty sure that I fibro since àbout the age of ten, but there was not a name associated with my pain and migraine headaches to label me during those years. I just learned to live with it. I slept a lot, and struggled with memory issues very early on. If anyone knows what a fibro body can look like…mine started to make obvious changes around the age of 23. I also felt my best when I was pregnant. It is my belief that this syndrome can be hereditary….as I am very sure that my father had it. Going back to the question at hand, Elavil has helped my symptoms alot. I am not dealing with depression by the way, just fibro pain and several of the other symptoms that goes along with it.

  • I’m also On Amitriptyline 50mg @ night gain weight, which does not help with my Arthritis joint pain,fibromyalgia, low vitamin D, & slip disk, my only other solution CBD, still trying to control my pain management constantly , still coping despite living with pain

  • I take fluoxitine for depression, 60mg and amitriptyline 10mg @ night for sleep and ativan 1mg for anxiety. I also have fibro, degenerative disc disease, TMJ, arthritis, IBS, tinnitus, plantar fasciitis, carpal tunnel, vertigo…… everyday is a silent battle.

  • I’ve been on 50mg of amitriptyline for about 9 years. I started with 10mg but my symptoms persisted. Using the dose to 25mg was still not working until I went to 50mg. I find that I am not getting the rest I need, anymore. My memory is brutal and my pain is managed by cannabis, the best. I have concern about the length of time I’ve been on it. I may try nortriptyline, instead. I’ll mention the other drugs and discuss further treatment with my doctor. I do have an inoperable meningioma and not sure of the symptoms that seems to coincide with fibromyalgia effects. It’s not an easy journey trying to manage the diagnosis of fibromyalgia and other ailments like IBS, arthritis and severe DDD in the neck. Keep on being your best advocate for better health and management.

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