A version of this drug called Low-Dose Naltrexone(LDN) is being used to treat fibromyalgia. It is given in small doses, to reduce pains caused by inflammatory and autoimmune conditions. Although it lacks concrete evidence, LDN has shown positive results for lessening daily pain, headaches and moodiness – typical symptoms of fibromyalgia, in a clinical study conducted by Standford researchers to invetigate the effects of LDN on pain patients.
There are several theories on how Naltrexone works for chronic pain:
LDN can potentially increase the level of endorphins, the neurotransmitter responsible to improve mood and carries natural pain relieving properties. This could play a part in helping to reduce symptoms of pain and depression of fibromyalgia.
LDN helps to lower microglial cell activities, in the central nervous system, which generates neuropathic pain and symptoms during an illness. It was speculated that the persistent pain and fatigue in fibromyalgia is due to an abnormally high level of activity in the microglial cell.