Recommended Use and Dosage
Despite the repercussions of the drug, pregabalin has an edge over the other two FDA approved fibromyalgia drugs, duloxetine and milnacipran, due to its unique effect in improving sleep, negligible effect on causing headaches and less severe side effects relating to the gastrointestinal tract.
The recommended dosage for pregabalin is 25–50 mg to be consumed in the night initially and increased weekly to 300-450 mg. However, the increment and ultimate dosage for every individual should be customized according to the tolerance and remedial response of the patient. The abovementioned study also suggests that pregabalin should be taken with food to reduce side effects. Patients are also advised to gradually reduce dosage and eventually stop entirely when patient sees improvement in the fibromyalgia symptoms.
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Sources:
- Boomershine CS. Pregabalin for the management of fibromyalgia syndrome. J Pain Res. 2010;3
- Hauser W, Bernardy K, Uceyler N, Sommer C. Treatment of fibromyalgia syndrome with gabapentin and pregabalin. A meta-analysis of randomized controlled trials. Pain. 2009;145(1–2):69–81. PubMed
- Straube S, Derry S, Moore RA, McQuay HJ. Pregabalin in fibromyalgia: meta-analysis of efficacy and safety from company clinical trial reports. Rheumatology. 2010;49:706–715. PubMed
- "Lyrica User Reviews for Fibromyalgia." Drugs.com. N.p., n.d. Web. 22 May. 2015.
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